Diagnosis and treatment of Langerhans cell histiocytosis (LCH) in elderly patients are often difficult.We report here a 61-year-old\nfemale suffering froma refractory axillary ulcer for nearly a year, whose biopsy revealed LCH. It was also noted that the patient had\nother cutaneous papulovesicular eruptions of LCH as well as central diabetes insipidus. The patient was first successfully treated\nwith multiagent chemotherapy (cytosine arabinoside/vinblastine/prednisolone). DDAVP also well controlled diabetes insipidus;\nhowever, the axillary ulcer and cutaneous LCH relapsed. Thereafter, we found topical imiquimod to be effective in the treatment of\nrelapsed cutaneous LCH lesions.
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